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《肝纤维化中西医结合诊疗指南》发布

发布时间:2007-12-30 作者:路人乙 来源:网络资源
  (四)调摄与护理   禁止饮酒、宜进清淡而富有营养的饮食。规律作息,劳逸结合,根据体力适当安排工作与生活,勿过劳。注意心理疏导以及原发病与并发症的调摄与护理。   (五)疗效评估   肝组织病理学检查是肝纤维化治疗的疗效判定的最重要依据,应积极提倡开展肝活组织的病理学检查以判定疗效。鉴于目前实际,可结合参考肝纤维化血清学标志物、血清肝功能酶学指标、证候等变化进行综合评价。   显效:经肝组织病理学检查肝纤维化分期下降≥2期;肝纤维化血清学标志物(ⅣC、HA、PⅢP及LN含量)两项以上测定值较治疗前下降≥50%或恢复正常;血清肝功能指标基本恢复正常,证候明显改善。   有效:肝纤维化血清学标志物(ⅣC、HA、LN及PⅢP含量)有任何两项测定值较治疗前下降≥25%;血清肝功能指标改善和(或)肝组织病理学检查肝纤维化分期较治疗前下降1期,证候改善。   无效:未达到有效标准者。   参 考 文 献   [1]Liaw YF, Tai DI, Chu CM, et al. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology, 1988, 8: 493-496.   [2]Hsu YS, Chien RN, Yeh CT, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology, 2002, 35: 1522-1527.   [3]Wu GC, Zhou WP, Zhao YR, et al. Study on the natural history of chronic hepatitis B. Zhonghua Ganzangbing Zazhi, 2002, 10: 46-48.   巫贵成,周卫平,赵有蓉,等.慢性乙型肝炎自然史的研究.中华肝脏病杂志,2002,10: 46-48.   [4]Hepatic Fibrosis Study Group of Chinese Liver Diseases Association. 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